Iodoethane → 4-Ethyl-6-(piperidin-4-yloxy)-isoquinoline

HRID 1022891Notes

Reaction equation

HRID 1022891 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([O:7][C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[CH:14]=[N:13][CH:12]=[C:11]3[CH2:18][CH2:19]CC(F)(F)F)[CH2:3][CH2:2]1.C(I)C>>[CH2:18]([C:11]1[C:10]2[C:15](=[CH:16][CH:17]=[C:8]([O:7][CH:4]3[CH2:5][CH2:6][NH:1][CH2:2][CH2:3]3)[CH:9]=2)[CH:14]=[N:13][CH:12]=1)[CH3:19]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 576470696-(Piperidin-4-yloxy)-4-(4,4,4-trifluoro-butyl)-isoquinoline

Product 1

HCID 576469074-Ethyl-6-(piperidin-4-yloxy)-isoquinoline

Procedure

The compound 266 was synthesized in a similar fashion as described for compound 90, using ethyl iodide. LCMS Method #1, retention time 0.98 min, detected mass 257.31 [M+H]+

Sources & evidence

ORD record
ord-3af8659262c14185a08a97cb65af6c80
Source dataset
uspto-grants-2014_05
Patent number
US08722671B2

Reaction notes

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