Sodium Carbonate → HCID 66859011, compound

HRID 1023033Notes

Reaction equation

HRID 1023033 reaction equation
Br[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:7]=1[N+:14]([O-:16])=[O:15])=[O:4].C(=O)([O-])[O-].[Na+].[Na+].Cl.[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[CH:28][C:27]=1[C:38]([F:41])([F:40])[F:39]>C(O)C>[CH3:13][O:12][C:9]1[CH:10]=[CH:11][C:6]([NH:5][C:3](=[O:4])[CH2:2][N:35]2[CH2:34][CH2:33][N:32]([C:29]3[CH:30]=[CH:31][C:26]([O:25][CH3:24])=[C:27]([C:38]([F:40])([F:41])[F:39])[CH:28]=3)[CH2:37][CH2:36]2)=[C:7]([N+:14]([O-:16])=[O:15])[CH:8]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 45865232-bromo-N-(4-methoxy-2-nitrophenyl)acetamideHCID 23149829HCID 23149829, compound

Product 1

HCID 66859011HCID 66859011, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Bromo-N-(4-methoxy-2-nitro-phenyl)-acetamide (6.7 g; 19.6 mmol) is dissolved in 200 ml ethanol in the presence of 6.3 g sodium carbonate. 1-(4-Methoxy-3-trifluoromethyl-phenyl)-piperazine hydrochloride (5.8 g; 19.6 mmol) is added to the resulting suspension and the mixture is stirred overnight at room temperature. The mixture is evaporated to dryness under vacuum and the residue is taken up with water and ethylacetate. The organic phase is separated and washed twice with water. After drying over magnesium sulfate, evaporation of the solvent leaves a residue which is triturated with ethylether.

Workup

  1. customThe mixture is evaporated to dryness under vacuum
  2. customThe organic phase is separated
  3. washwashed twice with water
  4. dry with materialAfter drying over magnesium sulfate, evaporation of the solvent
  5. customleaves a residue which
  6. customis triturated with ethylether

Sources & evidence

ORD record
ord-cd107eb19d4f4f8db05d00e43e011e34
Source dataset
uspto-grants-2014_05
Patent number
US08722682B2

Reaction notes

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