Sodium Carbonate → HCID 66859011, compound

Participants

Reaction Steps

2-Bromo-N-(4-methoxy-2-nitro-phenyl)-acetamide (6.7 g; 19.6 mmol) is dissolved in 200 ml ethanol in the presence of 6.3 g sodium carbonate. 1-(4-Methoxy-3-trifluoromethyl-phenyl)-piperazine hydrochloride (5.8 g; 19.6 mmol) is added to the resulting suspension and the mixture is stirred overnight at room temperature. The mixture is evaporated to dryness under vacuum and the residue is taken up with water and ethylacetate. The organic phase is separated and washed twice with water. After drying over magnesium sulfate, evaporation of the solvent leaves a residue which is triturated with ethylether.

Provenance & Evidence