Potassium Carbonate → (4-Cyclohexyl-phenyl)-(3-piperazin-1-yl-azetidin-1-yl)-methanone

HRID 1023038Notes

Reaction equation

HRID 1023038 reaction equation
[CH:1]1([C:7]2[CH:30]=[CH:29][C:10]([C:11]([N:13]3[CH2:16][CH:15]([N:17]4[CH2:22][CH2:21][N:20](C(=O)C(F)(F)F)[CH2:19][CH2:18]4)[CH2:14]3)=[O:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+]>CO.O>[CH:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:11]([N:13]3[CH2:16][CH:15]([N:17]4[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]4)[CH2:14]3)=[O:12])=[CH:29][CH:30]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 596260481-{4-[1-(4-Cyclohexyl-benzoyl)-azetidin-3-yl]-piperazin-1-yl}-2,2,2-trifluoro-ethanone

Product 1

HCID 59626057(4-Cyclohexyl-phenyl)-(3-piperazin-1-yl-azetidin-1-yl)-methanone

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of compound 1i (0.95 g, 2.24 mmol) in CH3OH (16 mL) and H2O (4 mL) was added K2CO3 (0.8 g, 5.79 mmol). The mixture was stirred at room temperature for 1 h. After filtration, the solvent was removed by evaporation. The crude compound 1j was used in the next reaction without further purification. MS m/z (M+H+) 328.2.

Workup

  1. filtrationAfter filtration
  2. customthe solvent was removed by evaporation
  3. customThe crude compound 1j was used in the next reaction without further purification

Sources & evidence

ORD record
ord-897672dfc04a41f3bc15ab5779a45ef6
Source dataset
uspto-grants-2014_05
Patent number
US08722658B2

Reaction notes

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