1,4-Benzodioxane-6-carboxylic Acid → HCID 178523674, compound

HRID 1023253Notes

Reaction equation

HRID 1023253 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1.[O:28]1[CH2:33][CH2:32][O:31][C:30]2[CH:34]=[C:35]([C:38](O)=[O:39])[CH:36]=[CH:37][C:29]1=2>>[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:38]([C:35]5[CH:36]=[CH:37][C:29]6[O:28][CH2:33][CH2:32][O:31][C:30]=6[CH:34]=5)=[O:39])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1

Participants

3

Reactant 2

HCID 27588331,4-Benzodioxane-6-carboxylic AcidHCID 178478587HCID 178478587, compound2×

Product 1

HCID 178523674HCID 178523674, compound

Procedure

The title compound, white solid (19 mg, 47.2%), MS (ISP) m/z=494.3 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine hydrochloride (Intermediate A) (30 mg, 81.5 mmol) and 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid.

Sources & evidence

ORD record
ord-33d1b90b8c414001bc37fc70e32f9588
Source dataset
uspto-grants-2014_05
Patent number
US08722683B2

Reaction notes

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