1-methyl-1H-imidazole-4-sulfonyl chloride → HCID 178481302, compound

HRID 1023269Notes

Reaction equation

HRID 1023269 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1.[CH3:28][N:29]1[CH:33]=[C:32]([S:34](Cl)(=[O:36])=[O:35])[N:31]=[CH:30]1>>[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][S:34]([C:32]5[N:31]=[CH:30][N:29]([CH3:28])[CH:33]=5)(=[O:36])=[O:35])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1

Participants

3

Reactant 2

HCID 27368871-methyl-1H-imidazole-4-sulfonyl chlorideHCID 178478587HCID 178478587, compound2×

Product 1

HCID 178481302HCID 178481302, compound

Procedure

The title compound, white solid (23 mg, 59.3%), MS (ISP) m/z=476.1 [(M+H)+], was prepared in accordance with the general method of example 66 from N-trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine hydrochloride (Intermediate A) (30 mg, 81.5 μmol) and 1-methyl-1H-imidazole-4-sulfonyl chloride.

Sources & evidence

ORD record
ord-74529c8d9da044dd8e8ac4d77618c7f7
Source dataset
uspto-grants-2014_05
Patent number
US08722683B2

Reaction notes

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