Hydrochloric Acid → HCID 66958856, compound

HRID 1023313Notes

Reaction equation

HRID 1023313 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[C:6]2[C:9]([NH:25][C@@H:26]3[CH2:30][CH2:29][NH:28][CH2:27]3)=[N:10][C:11]([C:13]3[CH:18]=[CH:17][C:16]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[CH:15][CH:14]=3)=[CH:12][C:5]=2[N:4]=[CH:3]1.[O:31]([C:33]#[N:34])[K].Cl>CO>[CH3:1][N:2]1[C:7](=[O:8])[C:6]2[C:9]([NH:25][C@@H:26]3[CH2:30][CH2:29][N:28]([C:33]([NH2:34])=[O:31])[CH2:27]3)=[N:10][C:11]([C:13]3[CH:18]=[CH:17][C:16]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[CH:15][CH:14]=3)=[CH:12][C:5]=2[N:4]=[CH:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 66958895HCID 66958895, compoundHCID 178418250HCID 178418250, compound

Product 1

HCID 66958856HCID 66958856, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (R)-3-methyl-7-(4-morpholinophenyl)-5-(pyrrolidin-3-ylamino)pyrido[4,3-d]pyrimidin-4(3H)-one (8.0 mg, 0.0197 mmol) in methanol (0.2 mL) were added KOCN (2.9 mg, 0.0354 mmol) and 1N aqueous HCl solution (19.7 μL, 0.0197 mmol). The reaction mixture was stirred at room temperature overnight, evaporated under vacuo, and purified by preparatory LC/MS to provide the title compound; HPLC-MS calculated for C23H27N7O3 (M+H+) 450.2, found 450.2.

Workup

  1. customevaporated under vacuo
  2. custompurified by preparatory LC/MS

Sources & evidence

ORD record
ord-6d1d19b8ab4a4ee9bd1cb73e3358f6ef
Source dataset
uspto-grants-2014_05
Patent number
US08722692B2

Reaction notes

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