Sodium Hydroxide → HCID 86673394, compound

HRID 1023363Notes

Reaction equation

HRID 1023363 reaction equation
C([O:5][C:6](=[O:32])/[CH:7]=[CH:8]/[C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[Cl:30])=[CH:18][N:17]=2)=[C:11]([F:31])[CH:10]=1)CCC.[OH-].[Na+]>CCO>[Cl:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[CH2:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([O:15][C:12]2[CH:13]=[CH:14][C:9](/[CH:8]=[CH:7]/[C:6]([OH:32])=[O:5])=[CH:10][C:11]=2[F:31])=[N:17][CH:18]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86673393HCID 86673393, compound

Product 1

HCID 86673394HCID 86673394, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

To an EtOH (40 mL) solution of the ester was added 5 M NaOH (6.9 mL), and stirred for 2.5 hours at 50° C., then EtOH was evaporated. The residue was dissolved in water, and acidified with 6 M HCl. The resulting precipitate was collected by filtration and dried to afford (E)-3-[4-({5-[(2-Chlorobenzyl)oxy]pyridin-2-yl}oxy)-3-fluorophenyl]prop-2-enoic acid as a white powder (2.78 g).

Workup

  1. customEtOH was evaporated
  2. dissolutionThe residue was dissolved in water
  3. filtrationThe resulting precipitate was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-0e625a8364e043329faba99e7c0d65de
Source dataset
uspto-grants-2014_05
Patent number
US08722663B2

Reaction notes

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