Sodium Hydroxide → HCID 86673394, compound

Participants

Reaction Conditions

Reaction Steps

To an EtOH (40 mL) solution of the ester was added 5 M NaOH (6.9 mL), and stirred for 2.5 hours at 50° C., then EtOH was evaporated. The residue was dissolved in water, and acidified with 6 M HCl. The resulting precipitate was collected by filtration and dried to afford (E)-3-[4-({5-[(2-Chlorobenzyl)oxy]pyridin-2-yl}oxy)-3-fluorophenyl]prop-2-enoic acid as a white powder (2.78 g).

Provenance & Evidence