反应详情

温度

50 °C

The crude 1-(2-Amino-pyridin-4-yl)-2-phenyl-propan-2-ol (120 mg) is dissolved in methylene chloride (4 mL). Then benzoyl isocynate (155 mg, 1.1 mmol) is added. The reaction mixture is sealed and heated at 50° C. for 16 hour. The solvent is then carefully removed and to the residue are added ethanol (5 mL) and potassium carbonate (73 mg, 0.53 mmol). The resulting mixture is heated at 85° C. for 2 hrs. Then solvent is removed to give the crude product which is purified by silica flash column chromatography using MeOH in DCM (gradient from 0% to 10%) to give 67 mg of the titled product.

1. customThe reaction mixture is sealed
2. customThe solvent is then carefully removed and to the residue
3. temperatureThe resulting mixture is heated at 85° C. for 2 hrs
4. customThen solvent is removed
5. customto give the crude product which
6. customis purified by silica flash column chromatography