反应详情

To a solution of 3-chloro-5-fluorophenol (1.46 g, 10 mmol) and 1-fluoro-4-nitrobenzene (1.41 g, 10 mmol) in acetonitrile (40 mL) was added potassium carbonate (2.76 g, 20 mmol) and the reaction mixture was heated to reflux for 4 hours. After filtration, the solvent was removed. The residue obtained was washed with n-hexane (2 times 15 mL) and dried to afford the title compound (2.38 g) which was directly used in the next step.

1. temperaturethe reaction mixture was heated
2. temperatureto reflux for 4 hours
3. filtrationAfter filtration
4. customthe solvent was removed
5. customThe residue obtained
6. washwas washed with n-hexane (2 times 15 mL)
7. customdried