Benzene, 2-methoxy-1-methyl-4-nitro- → 3-Methoxy-4-methylaniline

HRID 1023516노트

반응식

HRID 1023516 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[O:11][CH3:12]>CO>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[O:11][CH3:12]

참가 물질

3

반응물 1

HCID 83159Benzene, 2-methoxy-1-methyl-4-nitro-

생성물 1

HCID 278823-Methoxy-4-methylaniline수율 90.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 1-methyl-2-(methyloxy)-4-nitrobenzene (2.5 g, 14.96 mmol) in methanol (50 mL) Ni-Raney (˜2 g) was added and the reaction mixture was stirred overnight at room temperature under H2 atmosphere (1 atm). The catalyst was filtered off and the residue was purified by SCX cartridge (50 g) to afford the title compound (1.86 g) as a colourless oil.

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe residue was purified by SCX cartridge (50 g)

출처 및 근거

ORD 기록
ord-284f30a87eb9448e9690b14da0363fed
출처 데이터셋
uspto-grants-2014_05
특허 번호
US08722695B2

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