Calcium Hydroxide → HCID 67451161, compound

HRID 1023672Notes

Reaction equation

HRID 1023672 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[OH-].[Ca+2:34].[OH-]>O1CCCC1.O>[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[Ca:34]

Participants

4

Reactant 2

HCID 6093208Calcium HydroxideHCID 54671008Raltegravir

Product 1

HCID 67451161HCID 67451161, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

A physical mixture of Raltegravir free hydroxy (25.8 mg) and calcium hydroxide (˜4.6 mg) was suspended in 70/30 tetrahydrofuran/water. The mixture was shaken well and the resulting suspension was temperature cycled between room temperature and 50° C. using a Heidolph shaker and incubator with a power source programmed to switch on and off every 4 hours. After approximately 72 hours, excess solvent was decanted off using a syringe and the solid residue was dried at ambient temperature under vacuum for approximately 24 hours. The product was characterised by XRPD.

Workup

  1. customtemperature cycled between room temperature and 50° C.
  2. customoff every 4 hours
  3. customexcess solvent was decanted off
  4. customthe solid residue was dried at ambient temperature under vacuum for approximately 24 hours

Sources & evidence

ORD record
ord-61a625afa2fa4877bea23e511cd8c799
Source dataset
uspto-grants-2014_05
Patent number
US08722722B2

Reaction notes

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