Calcium Hydroxide → HCID 67451161, compound

Participants

Reaction Steps

A physical mixture of Raltegravir free hydroxy (25.8 mg) and calcium hydroxide (˜4.6 mg) was suspended in 70/30 tetrahydrofuran/water. The mixture was shaken well and the resulting suspension was temperature cycled between room temperature and 50° C. using a Heidolph shaker and incubator with a power source programmed to switch on and off every 4 hours. After approximately 72 hours, excess solvent was decanted off using a syringe and the solid residue was dried at ambient temperature under vacuum for approximately 24 hours. The product was characterised by XRPD.

Provenance & Evidence