Water → HCID 54736833, compound

Participants

Reaction Conditions

Reaction Steps

A three necked round bottom flask (100 ml) was charged with Raltegravir free hydroxy (5 g), ethanol (65 ml) and water (10 ml) to obtain a mixture. The obtained mixture was heated to 40° C. and a solution of tert-butylamine (1300 μl) in ethanol (2 ml) was added dropwise. After dissolution, the solution was cooled to room temperature. Precipitation occurred and the obtained solid was filtered under reduced pressure and dried overnight in a vacuum oven at 55° C. The resulting product was characterised by XRPD.

Provenance & Evidence