Water → HCID 54736833, compound

HRID 1023678Notes

Reaction equation

HRID 1023678 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.O.[C:34]([NH2:38])([CH3:37])([CH3:36])[CH3:35]>C(O)C>[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[C:34]([NH2:38])([CH3:37])([CH3:36])[CH3:35]

Participants

5

Reactant 3

HCID 962WaterHCID 6385Tert-ButylamineHCID 54671008Raltegravir

Product 1

HCID 54736833HCID 54736833, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
40 °C

Procedure

A three necked round bottom flask (100 ml) was charged with Raltegravir free hydroxy (5 g), ethanol (65 ml) and water (10 ml) to obtain a mixture. The obtained mixture was heated to 40° C. and a solution of tert-butylamine (1300 μl) in ethanol (2 ml) was added dropwise. After dissolution, the solution was cooled to room temperature. Precipitation occurred and the obtained solid was filtered under reduced pressure and dried overnight in a vacuum oven at 55° C. The resulting product was characterised by XRPD.

Workup

  1. customto obtain a mixture
  2. dissolutionAfter dissolution
  3. temperaturethe solution was cooled to room temperature
  4. customPrecipitation
  5. filtrationthe obtained solid was filtered under reduced pressure
  6. customdried overnight in a vacuum oven at 55° C

Sources & evidence

ORD record
ord-53e9516559884dfa81f264e49ccef68c
Source dataset
uspto-grants-2014_05
Patent number
US08722722B2

Reaction notes

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