Tert-Butylamine → HCID 54736833, compound

Participants

Reaction Steps

A three necked round bottom flask (100 ml) was charged with Raltegravir free hydroxy (5 g) and acetone (75 mL) to obtain a mixture. The obtained mixture was stirred and dissolved at room temperature. tert-Butylamine (1300 μl) in acetone (2 ml) was added dropwise. Heavy precipitation occurred and the obtained solid was filtered under reduced pressure and dried overnight in a vacuum oven at 55° C. The resulting product was characterised by XRPD.

Provenance & Evidence