Tert-Butylamine → HCID 54736833, compound

HRID 1023679Notes

Reaction equation

HRID 1023679 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[C:33]([NH2:37])([CH3:36])([CH3:35])[CH3:34]>CC(C)=O>[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[C:33]([NH2:37])([CH3:36])([CH3:35])[CH3:34]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 54671008Raltegravir

Product 1

HCID 54736833HCID 54736833, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A three necked round bottom flask (100 ml) was charged with Raltegravir free hydroxy (5 g) and acetone (75 mL) to obtain a mixture. The obtained mixture was stirred and dissolved at room temperature. tert-Butylamine (1300 μl) in acetone (2 ml) was added dropwise. Heavy precipitation occurred and the obtained solid was filtered under reduced pressure and dried overnight in a vacuum oven at 55° C. The resulting product was characterised by XRPD.

Workup

  1. customto obtain a mixture
  2. dissolutiondissolved at room temperature
  3. customHeavy precipitation
  4. filtrationthe obtained solid was filtered under reduced pressure
  5. customdried overnight in a vacuum oven at 55° C

Sources & evidence

ORD record
ord-2c5b9769f2c545018919beb07fbf75a2
Source dataset
uspto-grants-2014_05
Patent number
US08722722B2

Reaction notes

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