Diisopropylamine → HCID 54736835, compound

HRID 1023681Notes

Reaction equation

HRID 1023681 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[CH:33]([NH:36][CH:37]([CH3:39])[CH3:38])([CH3:35])[CH3:34]>C1(C)C=CC=CC=1>[CH3:1][C:2]1[O:6][C:5]([C:7]([NH:9][C:10]([C:13]2[N:19]([CH3:20])[C:17](=[O:18])[C:16]([OH:21])=[C:15]([C:22]([NH:24][CH2:25][C:26]3[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=3)=[O:23])[N:14]=2)([CH3:12])[CH3:11])=[O:8])=[N:4][N:3]=1.[CH:33]([NH:36][CH:37]([CH3:39])[CH3:38])([CH3:35])[CH3:34]

Participants

4

Reactant 2

HCID 7912DiisopropylamineHCID 54671008Raltegravir

Product 1

HCID 54736835HCID 54736835, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Raltegravir free hydroxy (25.2 mg) was suspended in toluene (0.250 mL), and diisopropylamine (8.7 μl) was added to the suspension. The mixture was shaken and the resulting suspension was temperature cycled between ambient and 50° C. using a Heidolph shaker and incubator with a power source programmed to switch on and off every 4 hours. After approximately 72 hours, excess solvent was decanted off using a syringe and the solid residue was dried at ambient temperature under vacuum for approximately 24 hours. The product was characterised by XRPD.

Workup

  1. custom50° C.
  2. customoff every 4 hours
  3. customexcess solvent was decanted off
  4. customthe solid residue was dried at ambient temperature under vacuum for approximately 24 hours

Sources & evidence

ORD record
ord-e0e10a3ec2b742e0b6f0911d7929c008
Source dataset
uspto-grants-2014_05
Patent number
US08722722B2

Reaction notes

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