Diisopropylamine → HCID 54736835, compound

Participants

Reaction Steps

Raltegravir free hydroxy (25.2 mg) was suspended in toluene (0.250 mL), and diisopropylamine (8.7 μl) was added to the suspension. The mixture was shaken and the resulting suspension was temperature cycled between ambient and 50° C. using a Heidolph shaker and incubator with a power source programmed to switch on and off every 4 hours. After approximately 72 hours, excess solvent was decanted off using a syringe and the solid residue was dried at ambient temperature under vacuum for approximately 24 hours. The product was characterised by XRPD.

Provenance & Evidence