Aniline → HCID 67045287, compound

HRID 1023693Notes

Reaction equation

HRID 1023693 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[CH2:13]Br.[CH2:16]([O:18][C:19](=[O:30])[CH2:20][CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=1)[CH3:17].NC1C=CC=CC=1>>[CH2:16]([O:18][C:19](=[O:30])[CH2:20][CH2:21][CH2:22][C:23]1[CH:24]=[CH:25][C:26]([N:29]2[CH2:13][C:5]3[C:4](=[CH:9][C:8]([N+:10]([O-:12])=[O:11])=[CH:7][CH:6]=3)[C:3]2=[O:15])=[CH:27][CH:28]=1)[CH3:17]

Participants

4

Reactant 3

HCID 6115AnilineHCID 10013251Ethyl 4-(4-aminophenyl)butanoateHCID 14552709Methyl 2-(bromomethyl)-5-nitrobenzoate

Product 1

HCID 67045287HCID 67045287, compound

Procedure

By using 2-bromomethyl-5-nitrobenzoic acid methyl ester and 4-(4-amino-phenyl)butyric acid ethyl ester instead of 2-bromomethyl-6-nitro-benzoic acid methyl ester and aniline used in Example 25, synthesis was performed in the same manner as that of Example 25 to obtain 4-[4-(6-nitro-1-oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-butyric acid ethyl ester.

Workup

  1. customused in Example 25, synthesis

Sources & evidence

ORD record
ord-4d0b073f327d469ca1b1ecd68f75a21a
Source dataset
uspto-grants-2014_05
Patent number
US08722723B2

Reaction notes

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