Chlorosulfonic acid → HCID 42633764, compound

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, 5 g of chlorosulphonic acid are introduced and are admixed at room temperature, in portions, with 3.6 g of 3-(trifluoromethyl)-1-(2,4-dimethylphenyl)-1H-1,2,4-triazole. The exothermic reaction raises the temperature of the mixture to around 45° C. The mixture is subsequently stirred at 70° C. for 3 hours and then cooled, and diluted with 20 ml of methylene chloride. The mixture is added with stirring to ice and then the phases are separated and washed with twice 20 ml of methylene chloride. The combined organic phases are concentrated on a rotary evaporator and then chromatographed (CH2Cl2). This gives 3.8 g of solid (76% of theory). This solid is reacted further directly.

Provenance & Evidence