Methyl(4-aminophenoxy)acetate → Methyl 4-[(4,5-diisopropylfuran-2-carbonyl)amino]phenyloxyacetate

HRID 1023705Notes

Reaction equation

HRID 1023705 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C:12]([OH:14])=O)[O:7][C:8]=1[CH:9]([CH3:11])[CH3:10])([CH3:3])[CH3:2].[NH2:15][C:16]1[CH:27]=[CH:26][C:19]([O:20][CH2:21][C:22]([O:24][CH3:25])=[O:23])=[CH:18][CH:17]=1>>[CH:1]([C:4]1[CH:5]=[C:6]([C:12]([NH:15][C:16]2[CH:27]=[CH:26][C:19]([O:20][CH2:21][C:22]([O:24][CH3:25])=[O:23])=[CH:18][CH:17]=2)=[O:14])[O:7][C:8]=1[CH:9]([CH3:10])[CH3:11])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 6422115Methyl(4-aminophenoxy)acetateHCID 584205144,5-Diisopropylfuran-2-carboxylic acid

Product 1

HCID 67396770Methyl 4-[(4,5-diisopropylfuran-2-carbonyl)amino]phenyloxyacetateYield 86%

Procedure

In the same manner as that of Example 2, 4,5-diisopropylfuran-2-carboxylic acid (60 mg, 0.306 mmol) was condensed with methyl 4-aminophenoxyacetate, and the resultant was purified by silica gel chromatography (0.5% methanol-chloroform) to obtain methyl 4-[(4,5-diisopropylfuran-2-carbonyl)amino]phenyloxyacetate (94 mg, 86%) as colorless needles.

Workup

  1. customthe resultant was purified by silica gel chromatography (0.5% methanol-chloroform)

Sources & evidence

ORD record
ord-defa4d11189149e19ca48c60bfedc7e5
Source dataset
uspto-grants-2014_05
Patent number
US08722730B2

Reaction notes

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