Methyl 4-aminobenzoate → HCID 67394987, compound

HRID 1023716Notes

Reaction equation

HRID 1023716 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C:12]([OH:14])=O)[S:7][C:8]=1[CH:9]([CH3:11])[CH3:10])([CH3:3])[CH3:2].[NH2:15][C:16]1[CH:25]=[CH:24][C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][CH:17]=1>>[CH:1]([C:4]1[CH:5]=[C:6]([C:12]([NH:15][C:16]2[CH:17]=[CH:18][C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:24][CH:25]=2)=[O:14])[S:7][C:8]=1[CH:9]([CH3:10])[CH3:11])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 12082Methyl 4-aminobenzoateHCID 58420519HCID 58420519, compound

Product 1

HCID 67394987HCID 67394987, compoundYield 86.3%

Procedure

In the same manner as that of Example 2, 4,5-diisopropylthiophene-2-carboxylic acid (86 mg, 0.406 mmol) was condensed with methyl 4-aminobenzoate (123 mg, 0.815 mmol), and the resultant was purified by silica gel chromatography [hexane-ethyl acetate (3:1)] to obtain methyl 4-[(4,5-diisopropylthiophene-2-carbonyl)amino]benzoate (121 mg, 86%) as colorless needles.

Workup

  1. customthe resultant was purified by silica gel chromatography [hexane-ethyl acetate (3:1)]

Sources & evidence

ORD record
ord-7e56b4e3042b4db4b0b42d7b7e29cf44
Source dataset
uspto-grants-2014_05
Patent number
US08722730B2

Reaction notes

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