Methyl 5-aminopyridine-2-carboxylate → HCID 67396482, compound

HRID 1023717Notes

Reaction equation

HRID 1023717 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C:12]([OH:14])=O)[S:7][C:8]=1[CH:9]([CH3:11])[CH3:10])([CH3:3])[CH3:2].[NH2:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]([O:24][CH3:25])=[O:23])=[N:20][CH:21]=1>>[CH:1]([C:4]1[CH:5]=[C:6]([C:12]([NH:15][C:16]2[CH:17]=[CH:18][C:19]([C:22]([O:24][CH3:25])=[O:23])=[N:20][CH:21]=2)=[O:14])[S:7][C:8]=1[CH:9]([CH3:10])[CH3:11])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 12457877Methyl 5-aminopyridine-2-carboxylateHCID 58420519HCID 58420519, compound

Product 1

HCID 67396482HCID 67396482, compoundYield 67%

Procedure

In the same manner as that of Example 2, 4,5-diisopropylthiophene-2-carboxylic acid (102 mg, 0.481 mmol) was condensed with methyl 5-aminopyridine-2-carboxylate, and the resultant was purified by silica gel chromatography [benzene-ethyl acetate (2:1)] to obtain methyl 5-[(4,5-diisopropylthiophene-2-carbonyl)amino]pyridine-2-carboxylate (112 mg, 67%) as colorless needles.

Workup

  1. customthe resultant was purified by silica gel chromatography [benzene-ethyl acetate (2:1)]

Sources & evidence

ORD record
ord-ba29a1df0e2e4c3ca5bea5c05e99240b
Source dataset
uspto-grants-2014_05
Patent number
US08722730B2

Reaction notes

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