Sodium Hydroxide → HCID 25189596, compound

HRID 1023720Notes

Reaction equation

HRID 1023720 reaction equation
[F:1][C:2]1[CH:11]=[C:10]([NH:12][C:13]([C:15]2[O:16][C:17]([CH:23]([CH3:25])[CH3:24])=[C:18]([CH:20]([CH3:22])[CH3:21])[CH:19]=2)=[O:14])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:11]=[C:10]([NH:12][C:13]([C:15]2[O:16][C:17]([CH:23]([CH3:25])[CH3:24])=[C:18]([CH:20]([CH3:21])[CH3:22])[CH:19]=2)=[O:14])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67395328HCID 67395328, compound

Product 1

HCID 25189596HCID 25189596, compoundYield 87.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of the aforementioned ester (92 mg, 0.265 mmol) in ethanol (5 ml) was added with 2 M aqueous sodium hydroxide (1 ml) to perform hydrolysis at room temperature for 4 hours, and extraction and recrystallization were performed to obtain the title compound (22, 77 mg, 86%) as colorless needles.

Workup

  1. customhydrolysis at room temperature for 4 hours
  2. extractionextraction and recrystallization

Sources & evidence

ORD record
ord-b7bab5cf577f4413bcda15187f6484c1
Source dataset
uspto-grants-2014_05
Patent number
US08722730B2

Reaction notes

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