Lithium Hydroxide → HCID 67395584, compound

HRID 1023728Notes

Reaction equation

[CH:1]([C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][C:14]([CH2:16][NH:17][C:18]2[CH:27]=[CH:26][C:21]([C:22]([O:24]C)=[O:23])=[CH:20][CH:19]=2)=[O:15])[O:7][C:8]=1[CH:9]([CH3:11])[CH3:10])([CH3:3])[CH3:2].[OH-].[Li+]>>[CH:1]([C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][C:14]([CH2:16][NH:17][C:18]2[CH:27]=[CH:26][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=2)=[O:15])[O:7][C:8]=1[CH:9]([CH3:10])[CH3:11])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 67395335HCID 67395335, compound

Product 1

HCID 67395584HCID 67395584, compoundYield 96%

Procedure

The ester obtained above (68 mg, 0.314 μmol) was hydrolyzed with lithium hydroxide in a conventional manner, and the residue was recrystallized to obtain the title compound (27, 63 mg, 96%) as colorless prisms.

Workup

customthe residue was recrystallized

Sources & evidence

ORD record: ord-3e115431b06f4083b5ef6d116351a217
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722730B2

Reaction notes

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