Lithium Hydroxide → HCID 67393999, compound

HRID 1023729Notes

Reaction equation

[CH:1]([C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][C:14]([NH:16][C:17]2[CH:18]=[C:19]([CH:25]=[CH:26][CH:27]=2)[C:20]([O:22]CC)=[O:21])=[O:15])[O:7][C:8]=1[CH:9]([CH3:11])[CH3:10])([CH3:3])[CH3:2].[OH-].[Li+]>>[CH:1]([C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][C:14]([NH:16][C:17]2[CH:18]=[C:19]([CH:25]=[CH:26][CH:27]=2)[C:20]([OH:22])=[O:21])=[O:15])[O:7][C:8]=1[CH:9]([CH3:10])[CH3:11])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 67394310HCID 67394310, compound

Product 1

HCID 67393999HCID 67393999, compoundYield 95%

Procedure

The ester obtained above (76 mg, 0.206 mmol) was hydrolyzed with lithium hydroxide in a conventional manner, and the residue was recrystallized to obtain the title compound (28, 67 mg, 95%) as pale yellow prisms.

Workup

customthe residue was recrystallized

Sources & evidence

ORD record: ord-ddbcb015d4b44412834bf615efbad71b
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722730B2

Reaction notes

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