HCID 86762399, compound → HCID 67277260, compound

HRID 1023767Notes

Reaction equation

HRID 1023767 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=2[O:19][CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=O)=[O:9]>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=2[O:19][CH2:20][C:21]([OH:23])=[O:22])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])=[O:9]

Participants

3

Reactant 1

HCID 86762399HCID 86762399, compound

Product 1

HCID 67277260HCID 67277260, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of the more polar product from Example 2 step d) (35 mg) in TFA (2 ml) was stirred for 24 h. The solvent was removed in vacuo, the mixture was azeotroped with toluene and purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent) to give the title compound (22 mg) as a white solid.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe mixture was azeotroped with toluene
  3. custompurified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent)

Sources & evidence

ORD record
ord-0298e4be90344ed08c72028118908fee
Source dataset
uspto-grants-2014_05
Patent number
US08722741B2

Reaction notes

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