Water → 4-(4-Bromo-2-trifluoromethyl-benzenesulfonyl)-morpholine

HRID 1023776Notes

Reaction equation

HRID 1023776 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Br:7][C:8]1[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[C:10]([C:18]([F:21])([F:20])[F:19])[CH:9]=1.O>C(Cl)Cl>[Br:7][C:8]1[CH:13]=[CH:12][C:11]([S:14]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)(=[O:15])=[O:16])=[C:10]([C:18]([F:21])([F:19])[F:20])[CH:9]=1

Participants

5

Reactant 3

HCID 962WaterHCID 8083MorpholineHCID 27786084-Bromo-2-(trifluoromethyl)benzenesulfonyl chloride

Product 1

HCID 473151804-(4-Bromo-2-trifluoromethyl-benzenesulfonyl)-morpholine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

Morpholine (1.1 ml) was added to a solution of [4-bromo-2-(trifluoromethyl)phenyl]sulfonyl chloride (2.03 g) in DCM (7 ml) at 0° C. and stirred at 20° C. for 16 h. Water was added and the mixture was extracted with DCM. The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-ether as eluent) to give the sub-title compound 2.10 g).

Workup

  1. extractionthe mixture was extracted with DCM
  2. dry with materialThe organic extracts were dried (MgSO4)
  3. customevaporated
  4. custompurified by chromatography (silica, petrol-ether as eluent)

Sources & evidence

ORD record
ord-8ef5ea1dc4bd41bebaed6f33a8730e1e
Source dataset
uspto-grants-2014_05
Patent number
US08722741B2

Reaction notes

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