HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1023776Generated: October 26, 2026
Water → 4-(4-Bromo-2-trifluoromethyl-benzenesulfonyl)-morpholine
https://huagongshe.com/reaction/1023776
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 4-Bromo-2-(trifluoromethyl)benzenesulfonyl chloride | HCID 2778608 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(4-Bromo-2-trifluoromethyl-benzenesulfonyl)-morpholine | HCID 47315180 | — |
Reaction Steps
Morpholine (1.1 ml) was added to a solution of [4-bromo-2-(trifluoromethyl)phenyl]sulfonyl chloride (2.03 g) in DCM (7 ml) at 0° C. and stirred at 20° C. for 16 h. Water was added and the mixture was extracted with DCM. The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-ether as eluent) to give the sub-title compound 2.10 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08722741B2 |
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| Source dataset | uspto-grants-2014_05 |
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| ORD ID | ord-8ef5ea1dc4bd41bebaed6f33a8730e1e |
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| Source note | uspto-grants-2014_05 |
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