2-Methylpyrrolidine → 1-[(3,5'-Dichloro-2'-methoxy[1,1'-biphenyl]-4-yl)carbonyl]-2-methyl-pyrrolidine

HRID 1023783Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:18]2[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=2[O:25][CH2:26]C(O)=O)[CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[C@@H:15](C)[CH2:14][CH2:13]C[C@H:11]1[CH3:17])=[O:9].CC1CCCN1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:18]2[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=2[O:25][CH3:26])[CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][CH2:13][CH:11]1[CH3:17])=[O:9]

Participants

Reactant 2

HCID 130032-Methylpyrrolidine

HCID 11517726[[3',5-dichloro-4'-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl][1,1'-biphenyl]-2-yl]oxy]-acetic acid

Product 1

HCID 686040621-[(3,5'-Dichloro-2'-methoxy[1,1'-biphenyl]-4-yl)carbonyl]-2-methyl-pyrrolidine

Procedure

The sub-title compound was prepared by the method of example 18 step a) using the product of step example 21 step a) and 2-methylpyrrolidine.

Sources & evidence

ORD record: ord-71d840da69db43d58f598e19044aaf87
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722741B2

Reaction notes

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