Pyrrolidine → (4-Bromo-2-methyl-phenyl)-pyrrolidin-1-yl-methanone

HRID 1023788Notes

Reaction equation

[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[CH:3]=1.[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:8])=[C:4]([CH3:11])[CH:3]=1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 995704-Bromo-2-methylbenzoic acid

Product 1

HCID 11818009(4-Bromo-2-methyl-phenyl)-pyrrolidin-1-yl-methanone

Procedure

The sub-title compound was prepared by the method of example 18 step a) using 4-bromo-2-methyl benzoic acid and pyrrolidine.

Sources & evidence

ORD record: ord-88d354c93752425c9707b14aa7df24cc
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722741B2

Reaction notes

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