反应详情

温度

80 °C

To a suspension of K2CO3 (2 mmol; 276 mg) in anhydrous acetonitrile (1 mL) under argon, was added 2-methoxy-4-ethylphenol (0.285 mL; 2 mmol) followed by 1-fluoro-4-nitro-2-(trifluoromethyl)benzene (418 mg; 2 mmol). The reaction mixture was stirred at 80° C. overnight. Concentrated under argon, washed with NaOH (0.1N; 3 mL), the mixture was extracted with ethyl acetate (2*3 mL). Combined organic phases were dried over MgSO4, concentrated in vacuo, to give the title product as a light brown oil (651 mg; 95%), used without further purification.

1. concentrationConcentrated under argon
2. washwashed with NaOH (0.1N; 3 mL)
3. extractionthe mixture was extracted with ethyl acetate (2*3 mL)
4. dry with materialCombined organic phases were dried over MgSO4
5. concentrationconcentrated in vacuo