Tetrahydrofuran → HCID 59191322, compound

HRID 1023989Notes

Reaction equation

HRID 1023989 reaction equation
[F:1][C:2]1[C:3]([CH:20]=[CH2:21])=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:17]=1)[O:7][C:8]1[C:9]([N+:14]([O-])=O)=[N:10][CH:11]=[CH:12][CH:13]=1.C1COCC1>CO>[CH2:20]([C:3]1[C:2]([F:1])=[CH:17][C:6]([O:7][C:8]2[C:9]([NH2:14])=[N:10][CH:11]=[CH:12][CH:13]=2)=[C:5]([O:18][CH3:19])[CH:4]=1)[CH3:21]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 59191223HCID 59191223, compound

Product 1

HCID 59191322HCID 59191322, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to the procedure of example 20(b) except substituting 4-ethyl-2-methoxy-1-[4-nitro-2-(trifluoromethyl)phenoxy]benzene by 3-(5-fluoro-2-methoxy-4-vinylphenoxy)-2-nitropyridine (3.7 mmol, 1.1 g) and THF by methanol, the title compound was prepared as a white solid (800 mg; 80.5%) and used without further purification.

Workup

  1. customused without further purification

Sources & evidence

ORD record
ord-263b2f6b0dc94e0586903a435ba303df
Source dataset
uspto-grants-2014_05
Patent number
US08722746B2

Reaction notes

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