HCID 86684120, compound → 6-Chloro-N-(5-(piperazin-1-yl)pyridine-2-yl)imidazo[1,2-a]pyridin-8-amine

HRID 1024013Notes

Reaction equation

HRID 1024013 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:11][C:12]2[N:17]=[CH:16][C:15]([N:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)=[CH:14][CH:13]=2)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1>Cl.O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[CH:16][N:17]=2)[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1

Participants

3

Reactant 1

HCID 86684120HCID 86684120, compound

Product 1

HCID 866841216-Chloro-N-(5-(piperazin-1-yl)pyridine-2-yl)imidazo[1,2-a]pyridin-8-amineYield 89.5%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

Compound 102a (1.75 g, 4.08 mmol) was suspended in 4.0 M HCl/dioxane (10 mL) and stirred at room temperature for 5 h. It was then concentrated under reduced pressure to afford 102b (1.2 g, 81%). MS: [M+H]+ 329.

Workup

  1. concentrationIt was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-0a55004dfd4d424893728828b998fd4a
Source dataset
uspto-grants-2014_05
Patent number
US08722676B2

Reaction notes

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