8-Bromo-6-chloroimidazo(1,2-b)pyridazine → 6-Chloro-N-(5-(4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine

Participants

Role	Name	HCID	Charge
Reactant	8-Bromo-6-chloroimidazo(1,2-b)pyridazine	HCID 46835269	—
Reactant	6-Chloro-N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine	HCID 86684123	—
Reactant	5-(4-(Oxetan-3-yl)piperazin-1-yl)pyridin-2-amine	HCID 86684125	—
Product	6-Chloro-N-(5-(4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine	HCID 86684124	77%

Reaction Steps

Following the procedures as described for compound 104b, 8-bromo-6-chloroimidazo[1,2-b]pyridazine 104a (233 mg, 1.0 mmol), and 5-(4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-amine (234 mg, 1.0 mmol) were reacted to give 105a as a white solid (296 mg, 77%). LCMS: [M+H]+ 386

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08722676B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-389810643e9147619e3f9579727240b6
Source note	uspto-grants-2014_05