Hydroxyamine hydrochloride → HCID 89542300, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 108a (2 g, 10 mmol) and hydroxylamine hydrochloride (1.4 g, 20 mmol) in MeOH (10 mL) was stirred at 100° C. for 0.5 h. The mixture was extracted with Ethyl acetate (20 mL×4) and the combined organic phase was washed with water. It was then concentrated under reduced pressure to afford 108b (2 g, 80%), which was used for next step without further purification. LCMS: [M+H]+ 250.

Provenance & Evidence