Hydroxyamine hydrochloride → HCID 89542300, compound

HRID 1024035Notes

Reaction equation

HRID 1024035 reaction equation
[Br:1][C:2]1[C:3](/[N:9]=[CH:10]/[N:11](C)C)=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl.N[OH:16]>CO>[Br:1][C:2]1[C:3](/[N:9]=[CH:10]/[NH:11][OH:16])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 89542360HCID 89542360, compound

Product 1

HCID 89542300HCID 89542300, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 108a (2 g, 10 mmol) and hydroxylamine hydrochloride (1.4 g, 20 mmol) in MeOH (10 mL) was stirred at 100° C. for 0.5 h. The mixture was extracted with Ethyl acetate (20 mL×4) and the combined organic phase was washed with water. It was then concentrated under reduced pressure to afford 108b (2 g, 80%), which was used for next step without further purification. LCMS: [M+H]+ 250.

Workup

  1. extractionThe mixture was extracted with Ethyl acetate (20 mL×4)
  2. washthe combined organic phase was washed with water
  3. concentrationIt was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-c91bdec594e044ae8272890e8238dc33
Source dataset
uspto-grants-2014_05
Patent number
US08722676B2

Reaction notes

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