反应详情

To a solution of intermediate D9 (1.07 g, 3.58 mmol) in THF (20 ml) stirred at −10° C. under N2 atmosphere, was added a 1.0 M solution of lithium aluminum hydride in THF dropwise (3.58 ml, 3.58 mmol). The resulting solution was gradually warmed to room temperature and further stirred for 2 hours. After cooling to 0° C. an aqueous 10% NaOH solution was carefully added and the resulting mixture was allowed to reach room temperature. Then it was extracted with DCM, dried (Na2SO4) and the solvent evaporated in vacuo to yield intermediate D10 (0.96 g, 99%) as a white solid that was used without further purification.

1. additionwas carefully added
2. customto reach room temperature
3. extractionThen it was extracted with DCM
4. dry with materialdried (Na2SO4)
5. customthe solvent evaporated in vacuo
6. customto yield intermediate D10 (0.96 g, 99%) as a white solid that
7. customwas used without further purification