Sodium Hydroxide → HCID 152782811, compound

HRID 1024419Notes

Reaction equation

HRID 1024419 reaction equation
[OH-].[Na+].C[O:4][C:5]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[OH:16])[NH:12][N:11]=[C:10]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=1)=[O:6]>O1CCOCC1>[C:5]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[OH:16])[NH:12][N:11]=[C:10]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=1)([OH:6])=[O:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 148095122HCID 148095122, compound

Product 1

HCID 152782811HCID 152782811, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4.5 4.23 ml of 2 N NaOH are added to a solution of 523 mg of “4d” in 10 ml of dioxane, and the mixture is heated under reflux for 1.5 hours. The mixture is subjected to conventional work-up, giving 386 mg of 5-carboxy-6-hydroxy-3-(3-methylbenzyl)-1H-indazole (“4e”).

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 1.5 hours

Sources & evidence

ORD record
ord-c95dac44ae7d483ab415c01328e84460
Source dataset
uspto-grants-2014_05
Patent number
US08722903B2

Reaction notes

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