HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenyl isocyanate → Methyl-3-methyl-2-(4-(4-(3-(4-(trifluoromethyl)phenyl)ureido)phenyl) thiazole-2-carboxamido)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenyl isocyanate | HCID 73768 | — |
| Reactant | Methyl 3-methyl-2-(4-(4-nitrophenyl)thiazole-2-carboxamido)butanoate | HCID 67150325 | — |
| Product | Methyl-3-methyl-2-(4-(4-(3-(4-(trifluoromethyl)phenyl)ureido)phenyl) thiazole-2-carboxamido)butanoate | HCID 52935054 | 79% |
Reaction Steps
The title compound was synthesized analogous to Example 23, using 1-isocyanato-4-(trifluoromethyl)benzene and intermediate 3. Yield: 79%; 1H NMR (DMSO-d6, 300 MHz): δ 9.14 (s, 1H), 8.99 (s, 1H), 8.80 (d, 1H), 8.32 (s, 1H), 8.06 (d, 2H), 7.66 (bs, 4H), 7.61 (d, 2H), 4.37 (s, 1H), 3.70 (s, 3H), 2.32 (m, 1H), 0.97 (s, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722901B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-f194bd948f8c4093835526bee5e86cf8 |
| Source note | uspto-grants-2014_05 |