4-tert-Butylbenzoyl chloride → Methyl 2-(5-(4-(4-tert-butylbenzamido)phenyl)-N-methylthiazole-2-carboxamido)-3-methylbutanoate

関与物質

役割	名称	HCID	仕込み量
反応物	4-tert-Butylbenzoyl chloride	HCID 74372	—
反応物	Methyl 3-methyl-2-(N-methyl-5-(4-nitrophenyl)thiazole-2-carboxamido)butanoate	HCID 67150337	—
生成物	Methyl 2-(5-(4-(4-tert-butylbenzamido)phenyl)-N-methylthiazole-2-carboxamido)-3-methylbutanoate	HCID 52935706	56%

反応手順

The title compound was synthesized analogous to Example 27, using 4-tert-butylbenzoyl chloride and intermediate 4. Yield: 56%; 1H NMR (DMSO-d6, 300 MHz): δ 10.38 (s, 1H), 8.37 (s, 1H), 8.04 (m, 4H), 7.78 (d, 2H), 7.57 (d, 2H), 6.27-4.76 (d, 1H), 3.69 (s, 3H), 3.47-2.95 (s, 3H), 2.35 (m, 1H), 1.33 (s, 9H), 1.11 (bs, 3H), 0.90 (bs, 3H); MS (ESI): m/z 508.2 [M+H]+.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08722901B2
出典データセット	uspto-grants-2014_05
ORD ID	ord-efb3820fee60420d8c503bc43f1c9074
出典メモ	uspto-grants-2014_05