Triethylamine → HCID 774372, compound

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	4-Bromobenzoyl chloride	HCID 68515	—
Reactant	6-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-1-(3-methyl-sulfanyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one	HCID 68941158	—
Solvent	Dichloromethane	HCID 6344	—
Product	HCID 774372	HCID 774372	—

Reaction Steps

4-Bromo-N-(4-chloro-phenyl)-benzamide (4) used is prepared by the following procedure. To a solution of 4-chloroaniline (2, 66.0 g, 517.4 mmol) and 4-bromobenzoyl chloride (3, 109.0 g, 497.5 mmol) in dichloromethane (1200 mL) is added triethyl amine (83.2 mL, 597.0 mmol). The reaction mixture is then poured into 0.05 N sodium hydroxide solution and the resulted suspension is stirred at rt for 1 h. The solid formed is filtered and washed well with water. It is dried in vacuo and used for the next step.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08722691B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-2c6e7193407643a0ba0ef2009d09bf49
Source note	uspto-grants-2014_05