Triethylamine → HCID 774372, compound

HRID 1024614Notes

Reaction equation

HRID 1024614 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)C(=O)C3C=NN(C4C=CC=C(C)C=4S)C=3N=2)=[CH:4][CH:3]=1.BrC1C=CC(C(Cl)=[O:39])=CC=1.C(N(CC)CC)C.[OH-].[Na+]>ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:9][C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=2)=[O:39])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 685154-Bromobenzoyl chlorideHCID 689411586-(4-Bromo-phenyl)-5-(4-chloro-phenyl)-1-(3-methyl-sulfanyl-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Product 1

HCID 774372HCID 774372, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Bromo-N-(4-chloro-phenyl)-benzamide (4) used is prepared by the following procedure. To a solution of 4-chloroaniline (2, 66.0 g, 517.4 mmol) and 4-bromobenzoyl chloride (3, 109.0 g, 497.5 mmol) in dichloromethane (1200 mL) is added triethyl amine (83.2 mL, 597.0 mmol). The reaction mixture is then poured into 0.05 N sodium hydroxide solution and the resulted suspension is stirred at rt for 1 h. The solid formed is filtered and washed well with water. It is dried in vacuo and used for the next step.

Workup

  1. customThe solid formed
  2. filtrationis filtered
  3. washwashed well with water
  4. customIt is dried in vacuo

Sources & evidence

ORD record
ord-2c6e7193407643a0ba0ef2009d09bf49
Source dataset
uspto-grants-2014_05
Patent number
US08722691B2

Reaction notes

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