反应详情

4-Bromo-N-(4-chloro-phenyl)-benzamide (3) used is prepared by the following procedure. To a solution of 4-chloroaniline (1, 66.0 g, 517.0 mmol) and 4-bromobenzoyl chloride (2, 109.0 g, 497.0 mmol) in dichloromethane (1200 mL) is added triethyl amine (83.0 mL, 596.0 mmol). The reaction mixture is then poured into 0.05 N sodium hydroxide solution and the resulted suspension is stirred at rt for 1 h. The solid formed is filtered and washed with water. The resulted white solid is dried under vacuum. The product is used in the next step reaction.

1. customThe solid formed
2. filtrationis filtered
3. washwashed with water
4. customThe resulted white solid is dried under vacuum
5. customThe product is used in the next step reaction