HCID 66818426, compound → HCID 66818768, compound

HRID 1024673Notes

Reaction equation

HRID 1024673 reaction equation
[C:1]([C:3]1[CH:35]=[CH:34][C:6]([O:7][C:8]2[C:13]([NH:14][S:15]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)(=[O:17])=[O:16])=[CH:12][CH:11]=[C:10]([O:25][C:26]3[CH:31]=[CH:30][C:29]([C:32]#[N:33])=[CH:28][CH:27]=3)[N:9]=2)=[CH:5][CH:4]=1)#[N:2]>C(O)C>[CH2:6]([O:7][C:1]([C:3]1[CH:35]=[CH:34][C:6]([O:7][C:8]2[C:13]([NH:14][S:15]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)(=[O:17])=[O:16])=[CH:12][CH:11]=[C:10]([O:25][C:26]3[CH:31]=[CH:30][C:29]([C:32]([O:25][CH2:10][CH3:11])=[NH:33])=[CH:28][CH:27]=3)[N:9]=2)=[CH:5][CH:4]=1)=[NH:2])[CH3:5]

Participants

3

Reactant 1

HCID 66818426HCID 66818426, compound

Product 1

HCID 66818768HCID 66818768, compoundYield 260.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2,6-Bis-(4-cyano-phenoxy)-3-(4-fluorobenzene-sulphonamido)-pyridine 0.3 g (0.61 mmol) was added to 70 ml of ethanol (saturated with HCl gas at −25° C.) and the reaction mixture was kept in a tight vessel at room temperature overnight. The reaction mixture was concentrated under reduced pressure to afford 0.46 g of the crude product which was taken for the next step without purification. Percentage purity: 51.1%, (M+1)=578.1+1.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-94a8b7c7c75d41e0be23e8fc5f9b4bd2
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

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