4-(2-Aminoethyl)piperidine, 4-BOC protected → HCID 66821595, compound

HRID 1024697Notes

Reaction equation

HRID 1024697 reaction equation
[C:1]([C:3]1[CH:30]=[CH:29][C:6]([O:7][C:8]2[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[C:10]([O:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][CH:19]=3)[N:9]=2)=[CH:5][CH:4]=1)#[N:2].[C:31]([O:35][C:36](=[O:46])[NH:37][CH2:38][CH2:39][CH:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1)([CH3:34])([CH3:33])[CH3:32]>>[C:31]([O:35][C:36](=[O:46])[NH:37][CH2:38][CH2:39][CH:40]1[CH2:41][CH2:42][N:43]([C:12]([C:11]2[C:10]([O:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]([F:26])([F:27])[F:28])=[CH:20][CH:19]=3)=[N:9][C:8]([O:7][C:6]3[CH:29]=[CH:30][C:3]([C:1]#[N:2])=[CH:4][CH:5]=3)=[CH:16][CH:15]=2)=[O:13])[CH2:44][CH2:45]1)([CH3:34])([CH3:32])[CH3:33]

Participants

3

Reactant 2

HCID 15018494-(2-Aminoethyl)piperidine, 4-BOC protectedHCID 66818709HCID 66818709, compound

Product 1

HCID 66821595HCID 66821595, compoundYield 66.5%

Procedure

6-(4-Cyano phenoxy)-2-(4-trifluoromethoxy phenoxy)nicotinic acid (0.15 g, 0.36 mmol) and (2-piperidin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.082 g, 0.36 mmol) were coupled using the procedure of Example 5(c) to afford 0.15 g of the required product. Percentage purity (LCMS): 43.23%.

Sources & evidence

ORD record
ord-8da125c9e84746bca19bbb936334b60f
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

Loading…