1-Piperazinecarboxylic acid, ethyl ester → HCID 66818527, compound

HRID 1024745Notes

Reaction equation

HRID 1024745 reaction equation
[C:1]([C:3]1[CH:19]=[CH:18][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:14]=[C:15]([OH:17])[CH:16]=2)[C:11]([OH:13])=O)=[CH:5][CH:4]=1)#[N:2].[CH2:20]([O:22][C:23]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)=[O:24])[CH3:21]>>[CH2:20]([O:22][C:23]([N:25]1[CH2:26][CH2:27][N:28]([C:11](=[O:13])[C:10]2[CH:14]=[C:15]([OH:17])[CH:16]=[C:8]([O:7][C:6]3[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:19][CH:18]=3)[CH:9]=2)[CH2:29][CH2:30]1)=[O:24])[CH3:21]

Participants

3

Reactant 2

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 66818647HCID 66818647, compound

Product 1

HCID 66818527HCID 66818527, compoundYield 37.4%

Procedure

Following the procedure of Example 5(c) 3-(4-cyano phenoxy)-5-hydroxy benzoic acid 0.9 g (3.52 mmol) and piperazine-1-carboxylic acid ethyl ester (0.556 g, 3.52 mmol) were used to afford 0.52 g of the required product. Percentage purity (LCMS): 90.2%, (M+1)=395.1+1.

Sources & evidence

ORD record
ord-2fb6ac5bc758479b9942ff0bb375edca
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

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