4-Bromobenzyl bromide → HCID 66818870, compound

HRID 1024747Notes

Reaction equation

HRID 1024747 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:29])[C:13]2[CH:18]=[C:17]([OH:19])[CH:16]=[C:15]([O:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][CH:22]=3)[CH:14]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[Br:30][C:31]1[CH:36]=[CH:35][C:34]([CH2:37]Br)=[CH:33][CH:32]=1>>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:29])[C:13]2[CH:14]=[C:15]([O:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][CH:22]=3)[CH:16]=[C:17]([O:19][CH2:37][C:34]3[CH:35]=[CH:36][C:31]([Br:30])=[CH:32][CH:33]=3)[CH:18]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 685274-Bromobenzyl bromideHCID 66818527HCID 66818527, compound

Product 1

HCID 66818870HCID 66818870, compoundYield 79.7%

Procedure

Using 0.75 g (1.89 mmol) of 4-[3-(4-cyano phenoxy)-5-hydroxy benzoyl]-piperazine-1-carboxylic acid ethyl ester and 1-bromo-4-bromomethyl-benzene (0.472 g, 1.89 mmol) and following the procedure of Example 42(b) afforded 0.85 g of the required product. Percentage purity (LCMS): 75.2%, (M+1)=563.1+1.

Sources & evidence

ORD record
ord-a953a6bc1f8a496b8da650c459e0a816
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

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